B25011 I By M. Faisal Hossain, BPharm, MPharm, PhD
What Is CoQ10?
Coenzyme Q10 (CoQ10) is a vitamin-like antioxidant produced naturally in the body and is essential for energy production in cells, especially in the heart and muscles. CoQ10 levels decline with age and are often depleted by statin medications. This has prompted interest in CoQ10 supplements for blood pressure control, cholesterol management, and statin-associated muscle pain.
CoQ10 in Hypertension: What Do Studies Show?
| Study | Daily Dose | Participants / Duration | Outcome |
|---|---|---|---|
| Sangouni et al., 2022 | 60 mg | 22 adults / 12 weeks | ⛔ No significant BP effect |
| Cicero et al., 2022 | 30 mg | 20 adults / 4 weeks | ✅ Reduced mean arterial pressure |
| Mazza et al., 2018 | 30 mg | 104 adults / 2 months | ✅ Reduced systolic & diastolic BP |
CoQ10 for Cholesterol & Statin-Induced Myopathy
📊 Table 1: Effect of CoQ10 Supplementation in Patients with High Cholesterol
| Study | Daily Dose | Participants | Outcomes |
|---|---|---|---|
| Zou et al., 2022 | 120 mg | 101 / 24 Weeks | ✅ Improved HDL function |
| Sangouni et al., 2022 | 60 mg | 88 / 12 Weeks | ⛔ No significant cholesterol benefit |
| Zhang et al., 2018 | 120 mg | 101 / 24 Weeks | ✅ Lowered triglycerides and LDL |
| Gholnari et al., 2018 | 100 mg | 50 / 12 Weeks | ⛔ No lipid profile changes |
Author Note: The author of this blog also published a peer-reviewed review article on this topic:🔗 Read the Full Article on “The American Journal of Natural Medicines, Facts”
This systematic review analyzed 22 clinical trials exploring the effects of CoQ10 on cholesterol levels and statin-associated muscle pain. Results suggest CoQ10—especially when combined with red yeast rice, berberine, or monacolin K—may significantly improve lipid profiles. Findings on muscle pain relief were mixed, highlighting the need for more research.
Safety, Dosing & Considerations
- Common doses: 30–200 mg/day
- Forms: Capsules or powder (see image below)
- Safety: Generally well-tolerated, but may interact with blood thinners or blood pressure meds
Final Thoughts
CoQ10 shows promise for supporting both blood pressure regulation and lipid health, especially when used in combination therapy. Although not a replacement for prescription medications, it may be a helpful adjunct under physician supervision.
We’d Love to Hear from You!
We’d Love to Hear from You!
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Reference
- Justus W, Hossain MF. Evaluating the Impact of CoQ10 on Dyslipidemia and Statin-induced Myopathy: A Systematic Review on Clinical Trials. Am J Nat Med Facts. 2024;1(2):1-6.
- Sangouni et al., 2022 | Cicero et al., 2022 | Mazza et al., 2018 | Young et al., 2012 | Burke et al., 2001
- Zou et al., 2022 | Zhang et al., 2018 | Gholnari et al., 2018 | Shojaei et al., 2011
Acknowledgment:
We used ChatGPT by OpenAI to refine grammar and improve readability.
Note: This blog is for informational purposes only. Consult your healthcare provider before starting any supplement.